Abstract |
Highly methoxylated flavones, which have known potential as cancer chemopreventive agents, accumulate on the leaf surfaces of some plant species and their physiological role is to protect the plant against harmful UV radiation. Xanthomicrol is one of the methoxylated flavones currently attracting most attention from researchers worldwide because of its promising pharmacological activities, including anti-spasmodic, anti-platelet and anti- cancer effects, among others. This review covers the chemistry and biological origin, distribution and pharmacological activity of xanthomicrol. Knowledge of the botanical distribution of this compound will not only encourage the use of plant sources for pharmacological purposes, but will also serve as a reference in the search for this valuable flavonoid in another genus or family. New approaches to xanthomicrol production are also described, including biotechnological attempts to develop xanthomicrol-producing plant cell factories.
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Authors | Mohammad Fattahi, Rosa M Cusido, Abbas Khojasteh, Mercedes Bonfill, Javier Palazon |
Journal | Mini reviews in medicinal chemistry
(Mini Rev Med Chem)
Vol. 14
Issue 9
Pg. 725-33
( 2014)
ISSN: 1875-5607 [Electronic] Netherlands |
PMID | 25138085
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Anti-Infective Agents
- Anticarcinogenic Agents
- Flavones
- Flavonoids
- Parasympatholytics
- Plant Extracts
- Platelet Aggregation Inhibitors
- xanthomicrol
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Topics |
- Anti-Infective Agents
(chemistry, isolation & purification, metabolism, pharmacology)
- Anticarcinogenic Agents
(chemistry, isolation & purification, metabolism, pharmacology)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Fabaceae
(chemistry)
- Flavones
(biosynthesis, chemistry, isolation & purification, pharmacology)
- Flavonoids
(biosynthesis, chemistry, isolation & purification, pharmacology)
- Humans
- Lamiaceae
(chemistry)
- Parasympatholytics
(chemistry, isolation & purification, metabolism, pharmacology)
- Plant Extracts
(chemistry)
- Platelet Aggregation Inhibitors
(chemistry, isolation & purification, metabolism, pharmacology)
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