Abstract | INTRODUCTION: METHODS: A series of pharmacophoric hybrids of substituted aryl semicarbazides incorporated into a fused triazolo- thiadiazole nucleus were synthesized and evaluated for neuropathic pain activity. After the assessment of neurotoxicity and peripheral analgesic activity, the compounds were evaluated in two peripheral neuropathic pain models, the chronic constriction injury and partial sciatic nerve ligation, to assess their antiallodynic and antihyperalgesic potential. RESULTS: CONCLUSION: Using a hybrid design approach, the present study identified novel chemical compounds that could be a potential lead for the treatment of neuropathic pain.
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Authors | Monika Sharma, Vanamala Deekshith, Arvind Semwal, Dharmarajan Sriram, Perumal Yogeeswari |
Journal | Pain and therapy
(Pain Ther)
Vol. 1
Issue 1
Pg. 3
(Dec 2012)
ISSN: 2193-8237 [Print] New Zealand |
PMID | 25134932
(Publication Type: Journal Article)
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