In vitro synergistic efficacy of conjugated linoleic acid, oleic acid, safflower oil and taxol cytotoxicity on PC3 cells.

Abstract

The aim of this study was to determine in vitro synergistic efficacy of conjugated linoleic acid (CLA), oleic acid (OLA), safflower oil and taxol (Tax) cytotoxicity on human prostate cancer (PC3) cell line. To determine synergistic efficacy of oil combinations, PC3 treated with different doses of compounds alone and combined with 10 μg/mL Tax. The MTT results indicated that OLA-Tax combinations exhibited cytotoxicity against PC3 at doses of 30 nM+10 μg-Tax, 15 nM+5 μg-Tax and 7.5 nM+2.5 μg-Tax. The treatment of OLA or Tax did not show significant inhibition on PC3, while OLA-Tax combinations showed effective cytotoxicity at treated doses. CLA-Tax combinations demonstrated the same effect on PC3 as combined form with 45.72% versus the alone form as 74.51% viability. Cytotoxic synergy between Tax, OLA and CLA shows enhanced cytotoxicity on PC3 which might be used in the therapy of prostate cancer.

• Authors: Sadi Kızılşahin, Ayşe Nalbantsoy, N Ülkü Karabay Yavaşoğlu
• Journal: Natural product research (Nat Prod Res) Vol. 29 Issue 4 Pg. 378-82 ( 2015) ISSN: 1478-6427 [Electronic] England
• PMID: 25134457 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Linoleic Acids, Conjugated
• Oleic Acid
• Safflower Oil
• Paclitaxel

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Cell Line, Tumor (drug effects)
• Drug Synergism
• Humans
• Linoleic Acids, Conjugated (pharmacology)
• Male
• Oleic Acid (pharmacology)
• Paclitaxel (pharmacology)
• Prostatic Neoplasms (pathology)
• Safflower Oil (pharmacology)