Abstract | BACKGROUND: METHODS: RESULTS: Of the 18 recipients, 8, 4, and 6 recipients received 1, 2, and 3 islet infusions, respectively. Overall graft survivals (defined as a C-peptide level ≥0.3 ng/mL) were 72.2%, 44.4%, and 22.2% at 1, 2, and 5 years, respectively, whereas the corresponding graft survivals after multiple infusions were 90.0%, 70.0%, and 30.0%, respectively. Three of these recipients achieved insulin independence in 14, 79, and 215 days. HbA1c levels and the requirement of exogenous insulin were improved before loss of graft function. All recipients became free of severe hypoglycemia unawareness, however, at least 5 of 14 patients who had graft failure experienced recurrence of severe hypoglycemia after the loss of graft function. CONCLUSIONS:
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Authors | T Anazawa, T Saito, M Goto, T Kenmochi, S Uemoto, T Itoh, Y Yasunami, A Kenjo, T Kimura, K Ise, T Tsuchiya, M Gotoh |
Journal | Transplantation proceedings
(Transplant Proc)
2014 Jul-Aug
Vol. 46
Issue 6
Pg. 1980-4
ISSN: 1873-2623 [Electronic] United States |
PMID | 25131088
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- C-Peptide
- Glycated Hemoglobin A
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Topics |
- Adult
- Aged
- C-Peptide
(blood)
- Death, Sudden, Cardiac
- Diabetes Mellitus, Type 1
(blood, surgery)
- Female
- Follow-Up Studies
- Glycated Hemoglobin
(metabolism)
- Graft Survival
- Humans
- Islets of Langerhans Transplantation
- Japan
- Male
- Middle Aged
- Time Factors
- Treatment Outcome
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