Grade 3 lymphomatoid granulomatosis in a patient receiving methotrexate therapy for rheumatoid arthritis.

Abstract

Lymphomatoid granulomatosis (LyG) is a rare, B-cell derived, lymphoproliferative disorder that often presents as pulmonary nodular lesions with a histopathology of lymphatic invasion of the vascular wall. The development of LyG may be associated with reactivation of the Epstein-Barr virus under an immunosuppressive state. We herein report a case of Grade 3 LyG that developed during methotrexate therapy for rheumatoid arthritis and regressed following the withdrawal of the drug.

• Authors: Hiroshi Oiwa, Keichiro Mihara, Takanobu Kan, Maiko Tanaka, Hajime Shindo, Kazuhiko Kumagai, Eiji Sugiyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 16 Pg. 1873-5 ( 2014) ISSN: 1349-7235 [Electronic] Japan
• PMID: 25130128 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antirheumatic Agents
• Glucocorticoids
• Sulfasalazine
• Prednisolone
• Methotrexate

Topics

• Aged
• Antirheumatic Agents (administration & dosage, adverse effects)
• Female
• Glucocorticoids (administration & dosage)
• Humans
• Lung Neoplasms (chemically induced, diagnostic imaging, drug therapy, pathology)
• Lymphomatoid Granulomatosis (chemically induced, diagnostic imaging, drug therapy, pathology)
• Methotrexate (administration & dosage, adverse effects)
• Prednisolone (administration & dosage)
• Radiography
• Sulfasalazine (administration & dosage)
• Treatment Outcome