Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview.

Abstract

Caveolin-1 plays an important role in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. Increased expression of caveolin-1 in an array of tumors has confirmed its value in prognosis. It has been established that oxidative stress is the main cause for loss of stromal caveolin-1 via autophagy in the tumor microenvironment. In this overview, we attempt to abridge the relationship between caveolin-1 and oral squamous cell carcinoma, taking all the established theories into consideration.

• Authors: Samapika Routray
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 10 Pg. 9487-95 (Oct 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25123270 (Publication Type: Journal Article, Review)

Chemical References

• CAV1 protein, human
• Caveolin 1

Topics

• Carcinoma, Squamous Cell (metabolism)
• Caveolin 1 (metabolism)
• Humans
• Mouth Neoplasms (metabolism)
• Tumor Microenvironment (physiology)