Abstract |
Streptococcus iniae infection has emerged as a serious fish health and economic problem in the global aquaculture operations. Current antibiotic options are few and possess severe practical limitations and potential adverse environmental impacts. The major factor contributing to the large burden of S. iniae disease in aquaculture is the lack of fundamental knowledge of innate immunity against the pathogen. In the present study, we use a tilapia model to explore which metabolites are crucial for the defense against the infection caused by S. iniae. We establish GC/MS based metabolic profile of tilapia liver and then compare the metabolic difference between survivals and the dying fish post the bacterial infection. We identify elevating N-acetylglucosamine in survival group as the most crucial metabolite differentiating the survivals from the dying in these fish infected by S. iniae. Exogenous N-acetylglucosamine significantly elevates survival ability of tilapia against the infection caused by S. iniae. Our findings highlight the importance of metabolic strategy against bacterial infections.
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Authors | Zhi-xue Cheng, Yan-mei Ma, Hui Li, Xuan-xian Peng |
Journal | Fish & shellfish immunology
(Fish Shellfish Immunol)
Vol. 40
Issue 2
Pg. 524-30
(Oct 2014)
ISSN: 1095-9947 [Electronic] England |
PMID | 25120218
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Adjuvants, Immunologic
- Acetylglucosamine
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Topics |
- Acetylglucosamine
(pharmacology)
- Adjuvants, Immunologic
(pharmacology)
- Animals
- Fish Diseases
(immunology, microbiology, mortality)
- Gas Chromatography-Mass Spectrometry
- Immunity, Innate
(drug effects)
- Metabolome
- Streptococcal Infections
(immunology, microbiology, mortality, veterinary)
- Streptococcus
(physiology)
- Survival Analysis
- Tilapia
(genetics, metabolism)
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