Targeting IgE to facilitate oral immunotherapy for food allergy: a potential new role for anti-IgE therapy?

Abstract

Food allergy is a major public health problem without satisfactory treatment options. Of several new treatments being studied, oral immunotherapy (OIT) appears to be the most promising. Unfortunately, OIT is associated with an unacceptably high frequency of allergic reactions. However, recent studies suggest that OIT might be made safer and faster when performed in conjunction with anti-IgE monoclonal antibody as an adjunctive treatment.

• Authors: Dale T Umetsu
• Journal: Expert review of clinical immunology (Expert Rev Clin Immunol) Vol. 10 Issue 9 Pg. 1125-8 (Sep 2014) ISSN: 1744-8409 [Electronic] England
• PMID: 25119422 (Publication Type: Editorial)

Chemical References

• Allergens
• Antibodies, Monoclonal
• Antigens, Plant
• Milk Proteins
• Immunoglobulin E

Topics

• Administration, Oral
• Allergens (adverse effects, immunology, therapeutic use)
• Anaphylaxis (etiology, prevention & control)
• Animals
• Antibodies, Monoclonal (therapeutic use)
• Antigens, Plant (administration & dosage, adverse effects)
• Arachis (immunology)
• Desensitization, Immunologic (methods, trends)
• Drug Therapy, Combination
• Food Hypersensitivity (immunology, therapy)
• Humans
• Immunoglobulin E (immunology)
• Milk (immunology)
• Milk Proteins (administration & dosage, adverse effects)