YAPping about differentiation therapy in muscle cancer.

Abstract

Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. In this issue of Cancer Cell, Tremblay and colleagues implicate YAP1 and the Hippo signaling pathway in the maintenance of differentiation-arrested and proliferative phenotypes for embryonal rhabdomyosarcoma.

• Authors: Matthew N Svalina, Charles Keller
• Journal: Cancer cell (Cancer Cell) Vol. 26 Issue 2 Pg. 154-5 (Aug 11 2014) ISSN: 1878-3686 [Electronic] United States
• PMID: 25117705 (Publication Type: Journal Article, Comment)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Adaptor Proteins, Signal Transducing
• Phosphoproteins
• Transcription Factors
• YAP-Signaling Proteins
• YAP1 protein, human

Topics

• Adaptor Proteins, Signal Transducing (physiology)
• Animals
• Cell Transformation, Neoplastic (metabolism)
• Humans
• Muscle Neoplasms (metabolism)
• Phosphoproteins (physiology)
• Rhabdomyosarcoma, Embryonal (metabolism)
• Satellite Cells, Skeletal Muscle (pathology)
• Transcription Factors
• YAP-Signaling Proteins