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Ferroquine as an oxidative shock antimalarial.

Abstract
Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.
AuthorsDaniel Dive, Christophe Biot
JournalCurrent topics in medicinal chemistry (Curr Top Med Chem) Vol. 14 Issue 14 Pg. 1684-92 ( 2014) ISSN: 1873-4294 [Electronic] United Arab Emirates
PMID25116581 (Publication Type: Journal Article)
Chemical References
  • Aminoquinolines
  • Antimalarials
  • Ferrous Compounds
  • Metallocenes
  • ferroquine
Topics
  • Aminoquinolines (chemistry, pharmacology)
  • Antimalarials (chemistry, pharmacology)
  • Ferrous Compounds (chemistry, pharmacology)
  • Hydrogen Bonding
  • Metallocenes
  • Oxidation-Reduction

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