Intracoronary injection of CD34-cells in chronic ischemic heart failure: 7 years follow-up of the DanCell study.

Abstract

OBJECTIVES:

Seven years ago, the DanCell study was carried out to test the hypothesis of improvement in left ventricular ejection fraction (LVEF) following repeated intracoronary injections of autologous bone marrow-derived stem cells (BMSCs) in patients suffering from chronic ischemic heart failure. In this post hoc analysis, the long-term effect of therapy is assessed.

METHODS:

32 patients [mean age 61 (SD ± 9), 81% males] with systolic dysfunction (LVEF 33 ± 9%) received two repeated intracoronary infusions (4 months apart) of autologous BMSCs (1,533 ± 765 × 10(6) BMSCs including 23 ± 11 × 10(6) CD34(+) cells and 14 ± 7 × 10(6) CD133(+) cells). Patients were followed for 7 years and deaths were recorded.

RESULTS:

During follow-up, 10 patients died (31%). In univariate regression analysis, the total number of BMSCs, CD34(+) cell count and CD133(+) cell count did not significantly correlate with survival (hazard ratio: 0.999, 95% CI: 0.998-1.000, p = 0.24; hazard ratio: 0.94, 95% CI: 0.88-1.01, p = 0.10, and hazard ratio: 0.96, 95% CI: 0.87-1.07, p = 0.47, respectively). After adjustment for baseline variables in multivariate regression analysis, the CD34(+) cell count was significantly associated with survival (hazard ratio: 0.90, 95% CI: 0.82-1.00, p = 0.04).

CONCLUSIONS:

Intracoronary injections of a high number of CD34(+) cells may have a beneficial effect on chronic ischemic heart failure in terms of long-term survival.

• Authors: Morten Hansen, Sebastian Nyby, Jacob Eifer Møller, Lars Videbæk, Moustapha Kassem, Torben Barington, Per Thayssen, Axel Cosmus Pyndt Diederichsen
• Journal: Cardiology (Cardiology) Vol. 129 Issue 2 Pg. 69-74 ( 2014) ISSN: 1421-9751 [Electronic] Switzerland
• PMID: 25116577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD34

Topics

• Adolescent
• Adult
• Aged
• Antigens, CD34
• Bone Marrow Transplantation (methods)
• Chronic Disease
• Female
• Follow-Up Studies
• Heart Failure (therapy)
• Humans
• Infusions, Intralesional
• Injections, Intralesional
• Male
• Middle Aged
• Myocardial Ischemia (therapy)
• Stem Cell Transplantation (methods)
• Transplantation, Autologous (methods)
• Treatment Outcome
• Ventricular Dysfunction, Left (therapy)
• Young Adult