Metastatic rhabdoid meningioma with BRAF V600E mutation and good response to personalized therapy: case report and review of the literature.

Abstract	Rhabdoid meningioma is an aggressive phenotype of meningioma, associated with a poor prognosis. We present a very rare case of high-grade meningioma with rhabdoid features that eventually expressed in a coma state. Comprehensive genomic profiling using a Next Generation Sequencing (NGS) assay revealed three genomic alterations: activating BRAF mutation (V600E), loss of CDKN2A/2B, and APC I1307K. After treatment with BRAF inhibitor (dabrafenib), the child's clinical condition improved progressively. After seven months, an MEK inhibitor was added (trametinib).
Authors	Oz Mordechai, Sergey Postovsky, Eugene Vlodavsky, Ayelet Eran, Shlomi Constantini, Eynat Dotan, Emmanuela Cagnano, Myriam Weyl-Ben-Arush
Journal	Pediatric hematology and oncology (Pediatr Hematol Oncol) Vol. 32 Issue 3 Pg. 207-11 (Apr 2015) ISSN: 1521-0669 [Electronic] England
PMID	25116269 (Publication Type: Case Reports, Journal Article, Review)
Chemical References	APC protein, human Adenomatous Polyposis Coli Protein Antineoplastic Agents Cyclin-Dependent Kinase Inhibitor p15 Cyclin-Dependent Kinase Inhibitor p16 Imidazoles Oximes Pyridones Pyrimidinones trametinib BRAF protein, human Proto-Oncogene Proteins B-raf dabrafenib
Topics	Adenomatous Polyposis Coli Protein (genetics) Antineoplastic Agents (therapeutic use) Child Cyclin-Dependent Kinase Inhibitor p15 (genetics) Cyclin-Dependent Kinase Inhibitor p16 (genetics) Female Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Imidazoles (therapeutic use) Magnetic Resonance Imaging Meningeal Neoplasms (drug therapy, genetics) Meningioma (drug therapy, genetics) Mutation (genetics) Oximes (therapeutic use) Precision Medicine Proto-Oncogene Proteins B-raf (antagonists & inhibitors, genetics) Pyridones (therapeutic use) Pyrimidinones (therapeutic use) Rhabdoid Tumor (drug therapy, genetics)

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