Abstract | INTRODUCTION: MATERIALS AND METHODS: 73 CCRCC patients who underwent radical nephrectomy or partial nephrectomy were enrolled. Immunohistochemical staining for N-WASP was performed on tissue microarrays constructed from tumor and para- tumor tissue obtained from these patients. The difference in N-WASP expression between tumor tissue and adjacent normal renal tissue was examined. Correlations between N-WASP expression in the tumor and clinicopathological parameters were analyzed and the relationship between N-WASP expression and overall survival also assessed. Uni- and multivariate survival analyses were performed. RESULTS: N-WASP expression was significantly reduced in tumor tissues and was significantly related to the histological grade of CCRCC. A higher level of N-WASP expression in the tumor was associated with relatively poor survival in CCRCC patients. The level of N-WASP expression, age at time of surgery, and histological grade were all responsible for clinical outcome in CCRCC patients. N-WASP was an independent predictor for overall survival. CONCLUSIONS: N-WASP was downregulated in CCRCC and could serve as a prognostic biomarker for predicting clinical outcome of CCRCC.
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Authors | Guang-Hua Liu, Jian Chen, Zhi-Gang Ji, Li Zhou |
Journal | Urologia internationalis
(Urol Int)
Vol. 95
Issue 1
Pg. 79-85
( 2015)
ISSN: 1423-0399 [Electronic] Switzerland |
PMID | 25115631
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 S. Karger AG, Basel. |
Chemical References |
- WASL protein, human
- Wiskott-Aldrich Syndrome Protein, Neuronal
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Topics |
- Aged
- Carcinoma, Renal Cell
(diagnosis, metabolism, physiopathology)
- Down-Regulation
- Female
- Follow-Up Studies
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Kidney Neoplasms
(diagnosis, metabolism, physiopathology)
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Metastasis
- Nephrectomy
- Prognosis
- Proportional Hazards Models
- Tissue Array Analysis
- Treatment Outcome
- Wiskott-Aldrich Syndrome Protein, Neuronal
(metabolism)
|