Cervical cancer (CC) is a
malignant neoplasm arising from cells originating in the cervix uteri, among the top causes of death from
cancer in women. In a gene expression profiling study of metabolic response to treatment, PI3K/Akt signaling pathway are associated with the development of CC. A common mechanism of Akt activation seen in
cancer types is alterations in the upstream regulators of Akt such as
phosphatidylinositol 3-kinase (PI3K), which is overexpressed in
cervical cancer tissues, and leads to phosphorylation of Akt. Both PI3K and Akt inhibitors exist and may be therapeutically valuable. In the present study, we use MTT assay and western blot for the high-throughput screening to select specific inhibitors of PI3K/Akt signaling pathway, and then obtain
fucoxanthin.
Fucoxanthin is a water-soluble
dietary fiber, taken from the unique slimy component of alginic cells. Various studies have pointed out that
fucoxanthin is very effective for the treatment of
cancer. Our results have shown that
fucoxanthin induced a significant apoptosis of HeLa cells, compared with other candidates.
After treatment with
fucoxanthin for 24 h, the level of phosphorylation was inhibited in a dose-dependent manner, and the
proteins of apoptotic markers were changed in HeLa cells. And
fucoxanthin could suppress
tumor growth in vivo. In addition, the mitochondrial signal transduction pathway maybe was involved in its mechanism and NF-κB activation was decreased
after treatment with
fucoxanthin. Therefore,
fucoxanthin may be used as anti-
cervical cancer drugs in the future.