Application of nuclear magnetic resonance spectroscopy for identification of ciprofloxacin crystalluria.

Abstract

This is a report describing a previously healthy young patient, who experienced crystalluria and non-cholestatic acute liver injury after a single intravenous dose of 400mg. The nuclear magnetic resonance spectra confirmed that the urinary sediment in our patient was formed by pure ciprofloxacin. The nuclear magnetic resonance spectra ((1)H NMR) of the urine sediment are a good test to confirm the composition of the crystals observed by electron microscopy and infrared spectrum. The findings indicate the importance of adequate hydration, urinalysis, measurement of pH and liver enzyme levels, prior to treatment with ciprofloxacin. Our findings also indicate that ciprofloxacin should not be administered to patients with renal tubular acidosis, due to their high urinary pH.

• Authors: Daniel Morell-Garcia, Bernardino Barceló, Adrian Rodriguez, Victor Liñeiro, Rosa Robles, Joan Vidal-Puigserver, Antonia Costa-Bauzá, Felix Grases
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 438 Pg. 43-5 (Jan 01 2015) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 25110814 (Publication Type: Letter)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Ciprofloxacin

Topics

• Adult
• Anti-Bacterial Agents (adverse effects, urine)
• Ciprofloxacin (adverse effects, urine)
• Crystallization
• Humans
• Male
• Microscopy, Electron
• Proton Magnetic Resonance Spectroscopy (methods)