Evaluation of long-term pituitary functions in patients with severe ventricular arrhythmia: a pilot study.
Abstract | INTRODUCTION: PATIENTS AND METHODS: Forty-four patients with ventricular arrhythmias [ ventricular tachycardia (VT), ventricular fibrillation (VF)] (mean age, 55.6 ± 1.8 years; 37 men, 7 women) were included in the study. The patients were evaluated after mean period of 21.2 ± 0.8 months from VT-VF. Basal hormone levels, including serum free triiodothyronine (fT3), free thyroxine (fT4), TSH, ACTH, prolactin, FSH, LH, total testosterone, estradiol, IGF-1, and cortisol levels were measured in all patients. To assess (GH)- insulin like growth factor-1 (IGF-1) axis, glucagon stimulation test was performed and 1 µg ACTH stimulation test was used for assessing hypothalamic-pituitary-adrenal (HPA) axis. RESULTS: The frequencies of GH, gonadotropin and TSH deficiency were 27.2, 9.0, 2.2%, respectively. Mean IGF-1 levels were lower in GH deficiency group, but it was not statistically significant. CONCLUSION: The present preliminary study showed that ventricular arrhythmias may result in hypopituitarism, particularly in growth hormone deficiency. Unrecognized hypopituitarism may be responsible for some of the cardiovascular problems at least in some patients.
|
Authors | Y Simsek, M G Kaya, F Tanriverdi, B Çalapkorur, H Diri, Z Karaca, K Unluhizarci, F Kelestimur |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 37
Issue 11
Pg. 1057-64
(Nov 2014)
ISSN: 1720-8386 [Electronic] Italy |
PMID | 25107344
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Cardiopulmonary Resuscitation
(adverse effects, trends)
- Female
- Humans
- Hypopituitarism
(blood, diagnosis, epidemiology)
- Male
- Middle Aged
- Pilot Projects
- Pituitary Diseases
(blood, diagnosis, epidemiology)
- Pituitary Gland
(physiology)
- Retrospective Studies
- Tachycardia, Ventricular
(blood, diagnosis, epidemiology)
- Ventricular Fibrillation
(blood, diagnosis, epidemiology)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|