Cyclophosphamide use in a young woman with antiphospholipid antibodies and recurrent cerebrovascular accident.

Abstract

We have described a 25-year-old woman with recurrent cerebral thrombosis associated with very high levels of antibodies against phospholipids. Antinuclear antibodies and clinical features of a defined connective tissue disease were absent. Treatment with plasmapheresis, prednisone, intravenous cyclophosphamide, and warfarin was accompanied by disappearance from the serum of the lupus anticoagulant and the biologic false-positive test for syphilis; IgG anticardiolipin antibodies persisted, however, and the patient had a second cerebral thrombosis. Clinical improvement ultimately occurred after the dosage of cyclophosphamide was optimized and the level of IgG anticardiolipin antibody decreased to a level lower than any that has been previously associated with thrombotic complications.

• Authors: M C Perez, W A Wilson, E Scopelitis
• Journal: Southern medical journal (South Med J) Vol. 82 Issue 11 Pg. 1421-4 (Nov 1989) ISSN: 0038-4348 [Print] United States
• PMID: 2510313 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies
• Blood Coagulation Factors
• Cardiolipins
• Immunoglobulin A
• Immunoglobulin G
• Lupus Coagulation Inhibitor
• Phospholipids
• Cyclophosphamide

Topics

• Adult
• Antibodies (analysis)
• Blood Coagulation Factors (analysis, immunology)
• Cardiolipins (immunology)
• Cerebral Infarction (drug therapy, immunology)
• Cyclophosphamide (therapeutic use)
• Female
• Humans
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Intracranial Embolism and Thrombosis (drug therapy, immunology)
• Lupus Coagulation Inhibitor
• Phospholipids (analysis)
• Recurrence