Abstract |
When administered as 300 micrograms b.d. or as 600 micrograms once in the evening, the new prostaglandin E1 analogue, rioprostil, is capable of reducing nocturnal H+ activity (1200 h to 0800 h) by 52% and 74%, respectively (p less than 0.01). Diurnal acidity (0900 h to 1800 h), on the other hand, is only reduced by 33% and 15% (not significant). A single evening dose of rioprostil, 600 micrograms, is used successfully on 208 patients suffering from acute duodenal ulcer. After 2 weeks and 4 weeks of treatment, the healing rates are comparable to the high values obtained with ranitidine, 300 mg nocte ( rioprostil, 600 micrograms nocte: 54.1% and 84.1%; ranitidine, 300 mg nocte: 54.4% and 89.9%). There are also no significant differences between the groups as regards symptomatic improvement. Severe diarrhoea and abdominal complaints do not occur with rioprostil, 600 micrograms nocte.
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Authors | H G Dammann, M Dreyer, P Müller, B Simon, P Demol |
Journal | Scandinavian journal of gastroenterology. Supplement
(Scand J Gastroenterol Suppl)
Vol. 164
Pg. 215-8
( 1989)
ISSN: 0085-5928 [Print] England |
PMID | 2510271
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Ulcer Agents
- Prostaglandins E
- Prostaglandins, Synthetic
- Rioprostil
- Ranitidine
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Topics |
- Adult
- Anti-Ulcer Agents
(administration & dosage, therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Duodenal Ulcer
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Prostaglandins E
(administration & dosage, therapeutic use)
- Prostaglandins, Synthetic
(administration & dosage, therapeutic use)
- Randomized Controlled Trials as Topic
- Ranitidine
(therapeutic use)
- Rioprostil
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