Influence of AKT on progesterone action in endometrial diseases.

Abstract

Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer.

• Authors: Irene I Lee, J Julie Kim
• Journal: Biology of reproduction (Biol Reprod) Vol. 91 Issue 3 Pg. 63 (Sep 2014) ISSN: 1529-7268 [Electronic] United States
• PMID: 25100707 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2014 by the Society for the Study of Reproduction, Inc.

Chemical References

• Progestins
• Receptors, Progesterone
• Progesterone
• AKT1 protein, human
• Proto-Oncogene Proteins c-akt

Topics

• Animals
• Cell Proliferation (drug effects)
• Endometrium (drug effects, metabolism, pathology)
• Female
• Humans
• Progesterone (therapeutic use)
• Progestins (therapeutic use)
• Proto-Oncogene Proteins c-akt (metabolism)
• Receptors, Progesterone (agonists, metabolism)
• Signal Transduction (drug effects)
• Uterine Diseases (drug therapy, metabolism, pathology)