Abstract | BACKGROUND: MATERIALS AND METHODS: A total of 40 formalin-fixed, paraffin-embedded tissue blocks of PA, and 20 blocks of MEC were included in this study. Diagnostic confirmation was performed through examination of hematoxylin and eosin sections. Both tumors were immunohistochemically analyzed for the presence of fascin using Avidin- Biotin complex method and evaluated via light microscope by 2 independent observers. Statistical analysis was performed using Kruskal-Wallis and Chi-square tests with significant level of P < 0.05. RESULTS: In both the tumors, the percentage of stained cells was significantly correlated with intensity of staining (P = 0.01 in PA and P = 0.00 in MEC). In PA, statistical analysis showed a significant direct correlation between percentage of stained cells and recurrence (P = 0.00). CONCLUSION:
Fascin might be a useful marker for recurrence of PAs and patients with high fascin expression in primary PA should be followed up periodically to detect potential recurrence as soon as possible.
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Authors | Sedigheh Rahrotaban, Faezeh Azmoudeh, Seyedeh Mahboubeh Kiyani |
Journal | Dental research journal
(Dent Res J (Isfahan))
Vol. 11
Issue 3
Pg. 370-4
(May 2014)
ISSN: 1735-3327 [Print] Iran |
PMID | 25097648
(Publication Type: Journal Article)
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