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Does tramadol affect coagulation status of patients with malignancy?

AbstractAIM:
The study investigated the direct effects of tramadol on the coagulation status of women with gynecologic malignancies in vitro.
MATERIALS AND METHODS:
Citrated whole-blood samples from 21 patients with gynecologic tumors were spiked ex vivo with 2 or 6 μl/ml tramadol. Thrombelastography (TEG) analysis was performed using ROTEM(®) to assess clotting time (CT), clot formation time (CFT) and maximum clot formation (MCF).
RESULTS:
In the INTEM assay, CT (P < 0.05) and CFT (P < 0.01) were significantly prolonged with tramadol at a 6 μl/ml concentration compared with baseline. There were no significant differences in MCF values between the baseline and the tramadol-treated samples (P > 0.05). Blood medicated with tramadol (6 μl/ml) clotted slowly (increased CT and CFT).
CONCLUSION:
The changes observed by TEG demonstrated that tramadol impairs hemostasis in a concentration-dependent manner in the whole blood of women with gynecologic malignancies in vitro.
AuthorsAyten Bilir, Meltem Olga Akay, Dilek Ceyhan, Neslihan Andıc
JournalIndian journal of pharmacology (Indian J Pharmacol) 2014 Jul-Aug Vol. 46 Issue 4 Pg. 413-5 ISSN: 1998-3751 [Electronic] India
PMID25097280 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Analgesics, Opioid
  • Tramadol
Topics
  • Analgesics, Opioid (administration & dosage, adverse effects, therapeutic use)
  • Blood Coagulation (drug effects)
  • Dose-Response Relationship, Drug
  • Endometrial Neoplasms (blood, drug therapy)
  • Female
  • Humans
  • Thrombelastography
  • Tramadol (administration & dosage, adverse effects, therapeutic use)
  • Uterine Cervical Neoplasms (blood, drug therapy)

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