The effect of the antioxidant drug "U-74389G" on oophoritis during ischemia reperfusion injury in rats.

Abstract

UNLABELLED:

The aim of this experiment was to study the effects of the antioxidant drug "U-74389G" on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean oophoritis (OI) lesions.

MATERIALS AND METHODS:

40 rats were used of mean weight 231.875 g. OI was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B were without the drug but C and D with U-74389G administration. Results were that U-74389G administration kept non-significantly increased the OI scores by 0.05±0.051 without lesions (p=0.3204). Reperfusion time kept non-significantly increased the OI scores by 0.05±0.051 also without lesions (p=0.3204). Nevertheless, U-74389G administration and reperfusion time together kept non-significantly increased the OI scores by 0.045±0.030 (p=0.1334).

CONCLUSIONS:

Results of this study indicate that U-74389G administration, reperfusion time and their interaction declined the increased OI scores from significant to non-significant level.

• Authors: Constantinos Τsompos, Constantinos Panoulis, Konstantinos Tauοutouzas, George Zetaografos, Apostolos Papalois
• Journal: Anti-inflammatory & anti-allergy agents in medicinal chemistry (Antiinflamm Antiallergy Agents Med Chem) Vol. 13 Issue 2 Pg. 103-7 ( 2014) ISSN: 1875-614X [Electronic] United Arab Emirates
• PMID: 25091819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Pregnatrienes
• U 74389F

Topics

• Animals
• Antioxidants (pharmacology)
• Disease Models, Animal
• Female
• Oophoritis (drug therapy)
• Pregnatrienes (pharmacology)
• Rats
• Rats, Wistar
• Reperfusion Injury (drug therapy)