Successful management of a childhood osteosarcoma with epiphysiolysis and distraction osteogenesis.

Abstract

In an 11-year-old boy with osteosarcoma in the proximal tibia (type iii), 2 cycles of dia chemotherapy (cisplatin, ifosfamide, doxorubicin) were administered preoperatively while epiphysiolysis was performed. Clinical response was determined to be complete by radiography and histopathology. Marginal excision was then performed with preservation of the proximal tibial epiphysis. Metaphyseal reconstruction was performed using distraction osteogenesis. Six cycles of dia chemotherapy were administered postoperatively. Twenty months later, the patient had developed no complications and experienced full bone healing, with no limb discrepancy. In selected adolescent patients with osteosarcoma, in whom the tumour is in full contact with the epiphysis, epiphyseal preservation by epiphysiolysis and reconstruction by distraction osteogenesis can provide an excellent outcome, resulting in a stable reconstruction that functionally restores the native limb.

• Authors: S F Xu, X C Yu, M Xu, X Chen
• Journal: Current oncology (Toronto, Ont.) (Curr Oncol) Vol. 21 Issue 4 Pg. e658-62 (Aug 2014) ISSN: 1198-0052 [Print] Switzerland
• PMID: 25089114 (Publication Type: Journal Article)