[Recovery of impaired respiratory activity in cats by thyroliberin analog (PR-546) devoid of hormonal properties].

Abstract

Synthetic analogue thyroliberin (PR-546) devoid of hormonal activity, recovered respiration in conditions of hyperventilation, two-sided vagotomy and hypoxia, caused by the 40-70% bleeding. PR-546 (in doses 100-500 micrograms/kg) intravenously injected was shown to abolish diagram activity decreased effect after hyperventilation. Injection of PR-546 to vagotomized cats in 1.5-2 h, increased breathing rate. The breathing activity resumed after long breaks in respiration as a result of peptide injection. The responses to analogue introductions is similar to the thyroliberin effect.

• Authors: I E Gurskaia, Ts V Serbeniuk, A D Sliuta, P Ia Romanovskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 108 Issue 7 Pg. 32-5 (Jul 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vosstanovlenie narushennoĭ dykhatel'noĭ aktivnosti koshek analogom tiroliberina (PR-546), lishennym gormonal'nykh svoĭstv.
• PMID: 2508786 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• PR 546
• Thyrotropin-Releasing Hormone

Topics

• Animals
• Cats
• Hyperventilation (physiopathology)
• Respiration (drug effects)
• Shock, Hemorrhagic (physiopathology)
• Thyrotropin-Releasing Hormone (pharmacology)
• Vagotomy