Abstract |
A 36-year-old woman complained of general malaise. She presented with hyponatremia and plasma osmotic pressure was lower than urinary osmotic pressure. In addition, serum antidiuretic hormone level was higher than the measurement sensitivity. She was diagnosed with the syndrome of inappropriate antidiuretic hormone secretion ( SIADH). She fell into a coma despite correction of serum sodium level. Brain magnetic resonance imaging (MRI) revealed high signal intensities in the cerebral cortex, striatum, thalamus, hypothalamus, midbrain, and pons in fluid-attenuated inversion recovery images. Spinal MRI revealed a longitudinally extending lesion in the cervical cord. Serum sample was positive for anti-aquaporin-4 antibody, supporting the diagnosis of neuromyelitis optica spectrum disorder (NMOSD) combined with central pontine and extrapontine myelinolysis. In patients with NMOSD, the immune reaction can gradually cause destructive changes of the hypothalamus and lead to unstable ADH secretion in the absence of immunomodulatory treatment.
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Authors | Waka Sakai, Naoko Matsui, Koji Fujita, Yuishin Izumi, Yoshihiko Nishida, Toshiyuki Takahashi, Takashi Kanbayashi, Ryuji Kaji |
Journal | Rinsho shinkeigaku = Clinical neurology
(Rinsho Shinkeigaku)
Vol. 54
Issue 7
Pg. 556-60
( 2014)
ISSN: 1882-0654 [Electronic] Japan |
PMID | 25087556
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- AQP4 protein, human
- Aquaporin 4
- Biomarkers
- Sodium
- Prednisolone
- Methylprednisolone
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Topics |
- Adult
- Aquaporin 4
(blood)
- Biomarkers
(blood)
- Brain
(pathology)
- Humans
- Inappropriate ADH Syndrome
(complications, diagnosis, therapy)
- Magnetic Resonance Imaging
- Male
- Methylprednisolone
(administration & dosage)
- Myelinolysis, Central Pontine
(complications, diagnosis, therapy)
- Neuromyelitis Optica
(complications, diagnosis, therapy)
- Plasma Exchange
- Prednisolone
(administration & dosage)
- Pulse Therapy, Drug
- Sodium
(blood)
- Treatment Outcome
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