Abstract | BACKGROUND: METHODS: A literature search focusing on dysregulation of Klotho and its possible mechanisms in cancer was performed. RESULTS AND CONCLUSIONS: Downregulation of Klotho was found in several cancers, such as pancreatic cancer, HCC, and other tumors. Epigenetic modulation, such as promoter methylation and histone deacetylation, also contributed to the dysregulation of Klotho in cancers. Downregulation of Klotho resulted in promoted proliferation and reduced apoptosis of cancer cells. The relevant mechanisms include the fibroblast growth factor signaling, the insulin-like growth factor 1 receptor pathway, and the Wnt/β- catenin signaling pathway. Furthermore, the Klotho protein hopefully provides new insights into cancer target treatment.
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Authors | Xiangxiang Zhou, Xin Wang |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 141
Issue 6
Pg. 961-9
(Jun 2015)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 25086986
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Biomarkers, Tumor
- Fibroblast Growth Factors
- Receptor, IGF Type 1
- Glucuronidase
- Klotho Proteins
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Topics |
- Animals
- Apoptosis
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(metabolism)
- Carcinoma, Hepatocellular
(metabolism)
- Cell Proliferation
- Down-Regulation
- Fibroblast Growth Factors
(metabolism)
- Gene Expression Regulation, Neoplastic
- Glucuronidase
(metabolism)
- Humans
- Klotho Proteins
- Liver Neoplasms
(metabolism)
- Lung Neoplasms
(metabolism)
- Neoplasms
(metabolism)
- Receptor, IGF Type 1
(metabolism)
- Signal Transduction
- Wnt Signaling Pathway
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