Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: GlyFn serum levels in the first trimester were significantly higher in women with preeclampsia (P < .01) and remained higher throughout pregnancy (P < .01). GlyFn, sFlt1, PlGF, and the sFlt1/PlGF ratio were significantly associated (P < .01) with preeclampsia status, and the classification performance of these analytes represented by area under the receiver operating characteristic curve was 0.99, 0.96, 0.94, and 0.98, respectively, with 95% confidence intervals of 0.98-1.00, 0.89-1.00, 0.86-1.00, and 0.94-1.00, respectively. Increased GlyFn levels were significantly associated with gestational age at delivery (P < .01), blood pressure (P = .04), and small-for-gestational-age neonates. Repeated-measures analysis of the difference in weekly GlyFn change in the third trimester demonstrated that mild preeclampsia was associated with a weekly change of 81.7 μg/mL (SE 94.1) vs 195.2 μg/mL (SE 88.2) for severe preeclampsia. The GlyFn POC demonstrated similar performance to a plate assay with an area under the receiver operating characteristic curve of 0.93 and 95% confidence interval of 0.85-1.00. CONCLUSION: GlyFn is a robust biomarker for monitoring of preeclampsia in both a standard and POC format, which supports its utility in diverse settings.
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Authors | Juha Rasanen, Matthew J Quinn, Amber Laurie, Eric Bean, Charles T Roberts Jr, Srinivasa R Nagalla, Michael G Gravett |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 212
Issue 1
Pg. 82.e1-9
(Jan 2015)
ISSN: 1097-6868 [Electronic] United States |
PMID | 25086276
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Fibronectins
- Glycation End Products, Advanced
- PGF protein, human
- Pregnancy Proteins
- glycated fibronectin
- Placenta Growth Factor
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Topics |
- Adolescent
- Adult
- Biomarkers
(blood)
- Female
- Fibronectins
(blood)
- Glycation End Products, Advanced
- Humans
- Placenta Growth Factor
- Point-of-Care Systems
- Pre-Eclampsia
(blood, diagnosis)
- Pregnancy
- Pregnancy Proteins
- Young Adult
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