The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells.

Abstract

Here, we show that cell surface β1-integrin expression, cell adhesion to fibronectin, migration, and invasion were all significantly inhibited by α-lipoic acid. These effects were not observed when cells were treated with dihydrolipoic acid or caprylic acid. These data reveal that the 1,2-dithiolane structure plays an important role in the action of α-lipoic acid.

• Authors: Masao Yamasaki, Shozen Soda, Yoichi Sakakibara, Masahito Suiko, Kazuo Nishiyama
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 78 Issue 11 Pg. 1939-42 ( 2014) ISSN: 1347-6947 [Electronic] England
• PMID: 25081893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1,2-dithiolane
• Integrin beta1
• Thioctic Acid

Topics

• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Down-Regulation (drug effects)
• Humans
• Integrin beta1 (genetics)
• Thioctic Acid (analogs & derivatives, chemistry, pharmacology)
• Urinary Bladder Neoplasms (metabolism)