The use of osteochondral allograft with bone marrow-derived mesenchymal cells and hinge joint distraction in the treatment of post-collapse stage of osteonecrosis of the femoral head.

Osteonecrosis of the femoral head is an entity which occurs mainly in young and active patients aged between 20 and 50. The success of hip joint preserving treatments ranges from 15% to 50% depending on the stage and amount of osteonecrotic lesion. Total hip replacement is indicated in late post-collapse hips but it has unsatisfactory survival because of the wear and osteolysis in young and active patients. Osteochondral allografts have been reported in the treatment of large articular lesions with defects in underlying bone in knee, talus and shoulder. By combining osteoconductive properties of osteochondral allograft with osteogenic abilities of bone marrow-derived mesenchymal cells it has a potential to be an alternative to an autologous graft. The adjunct of hinged joint distraction should minimize stresses in subchondral bone to promote creeping substitution and prevent femoral head collapse. Unlike current treatment modalities, it would provide both structural support and allow bony and articular substitution.
AuthorsJ Gagala, M Tarczynska, K Gaweda, L Matuszewski
JournalMedical hypotheses (Med Hypotheses) Vol. 83 Issue 3 Pg. 398-400 (Sep 2014) ISSN: 1532-2777 [Electronic] United States
PMID25081504 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
  • Allografts
  • Bone Marrow (pathology)
  • Bone Marrow Cells (cytology)
  • Femur (pathology, physiopathology)
  • Femur Head (surgery)
  • Femur Head Necrosis (physiopathology, therapy)
  • Hip Joint (physiopathology)
  • Humans
  • Joint Diseases (physiopathology)
  • Joints (physiopathology)
  • Mesenchymal Stromal Cells (cytology)
  • Osteonecrosis (pathology, physiopathology, therapy)

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