Abstract | CONTEXT: OBJECTIVES: Our aim was to study the associations between HDL apolipoprotein ( apo)-A-I fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and estimates of liver and visceral and sc fat. DESIGN: RESULTS: In a multivariate analysis, among the morphological and biological parameters that may predict apoA-I FCR, liver fat (β = .400, P = .003), and VLDL1-apoB (β = .307, P = .020) were independently associated with apoA-I FCR. In a multivariate analysis, among the kinetic parameters, VLDL1-triglycerides (TGs) indirect FCR (β = -.357, P = .001), VLDL1-TG production rate (β = 0.213, P = .048), and apoA-II FCR (β = .667, P < .0001) were independently associated with apoA-I FCR. After adjustment for VLDL1-TG production rate, liver fat was no more correlated with apoA-I FCR. No association between apoA-I FCR and visceral fat was observed. CONCLUSIONS: We show that VLDL1 is an important independent determinant of apoA-I FCR and more precisely that apoA-I FCR is independently associated with both catabolism and the production of VLDL1-TG. In addition, we show an association between liver fat and apoA-I FCR that is mostly mediated by VLDL1-TG production. These data indicate that, in abdominal obesity, dysfunctional VLDL1 metabolism is an important modulator of HDL apoA-I catabolism.
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Authors | Bruno Vergès, Martin Adiels, Jan Boren, Peter Hugh Barrett, Gerald F Watts, Dick Chan, Laurence Duvillard, Sanni Söderlund, Niina Matikainen, Juhani Kahri, Isabelle Robin, Marja-Riitta Taskinen |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 99
Issue 11
Pg. 4281-90
(Nov 2014)
ISSN: 1945-7197 [Electronic] United States |
PMID | 25077901
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins
- Lipoproteins, HDL
- Lipoproteins, VLDL
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Topics |
- Adipose Tissue
(metabolism)
- Adult
- Aged
- Apolipoproteins
(metabolism)
- Female
- Humans
- Lipoproteins, HDL
(metabolism)
- Lipoproteins, VLDL
(metabolism)
- Liver
(metabolism)
- Male
- Middle Aged
- Obesity, Abdominal
(metabolism)
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