Abstract | BACKGROUND: METHODS: One hundred and seventy two patients received neoadjuvant chemoradiotherapy for rectal cancer and underwent surgery. Patients were divided into two groups based on presence of acellular mucin pools. Locoregional failures, distant failures and deaths were compared. Expected 5 year disease free and overall survival was calculated. RESULTS: Median follow-up was 36(4-94) months. Complete pathological response was identified in 35(20.3%) patients. Of these, 12(34.2%) had acellular mucin pools in resected specimen. Majority of mucin negative tumors were moderately differentiated (78% vs 25%) (P = 0.005). Median overall survival for mucin positive and mucin negative tumors was 4(1.3-5.7) and 3.3(0.1-6.3) years respectively. Expected 5 year disease free and overall survival for mucin positive and mucin negative tumors was 73% and 89% (P = 0.1) and 75% and 87% (P = 0.4). CONCLUSION:
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Authors | Abu Bakar Hafeez Bhatti, Ali Akbar, Shahid Khattak, Ather Saeed Kazmi, Aarif Jamshed, Aamir Ali Syed |
Journal | International journal of surgery (London, England)
(Int J Surg)
Vol. 12
Issue 10
Pg. 1123-6
(Oct 2014)
ISSN: 1743-9159 [Electronic] England |
PMID | 25072703
(Publication Type: Journal Article)
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Copyright | Copyright © 2014. Published by Elsevier Ltd. |
Chemical References |
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Topics |
- Adult
- Aged
- Carcinoma
(metabolism, mortality, therapy)
- Cell-Free System
- Chemoradiotherapy
- Female
- Humans
- Male
- Middle Aged
- Mucins
(metabolism)
- Neoadjuvant Therapy
- Prognosis
- Rectal Neoplasms
(metabolism, mortality, therapy)
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