Therapeutic outcomes of retinal hemangioblastomas.

Abstract

PURPOSE:

To report the results of treatments and therapeutic complications of retinal hemangioblastomas (RH).

METHODS:

Retrospective consecutive case series. Data from 32 patients (37 eyes) with RH were reviewed for characteristics of RH and treatment outcomes.

RESULTS:

Among 32 patients, we identified 73 RHs in 37 eyes. At baseline, 24 of 37 eyes (65%) had 20/50 visual acuity or better, 8 eyes (22%) had intermediate vision (20/400-20/50), and 5 eyes (13%) had poor vision (≤20/400). Seven RHs (9.6%) were located in the juxtapapillary area, and 66 RHs (90.4%) were located in peripheral area. Small RHs (54.8%; <0.5 mm in size) were treated with laser photocoagulation, moderate-sized RHs (24.7%; 0.5-3.0 mm in size) were treated with transpupillary thermotherapy, and large RHs (20.5%; >3.0 mm in size) were treated with a combination of transpupillary thermotherapy and cryotherapy. After treatment, 90% of small RHs regressed, whereas only 67% of large RHs regressed (P = 0.044). Peripheral RHs showed better response to treatment than juxtapapillary RHs (P = 0.010). Treatment-related complications occurred in 5 eyes (14%), and 1-step combination therapy was applied more frequently in the complication group (P = 0.048).

CONCLUSION:

Small RHs in peripheral areas may require aggressive treatment because they respond well to treatment. In larger RHs, staged treatment could reduce treatment-related complications. Transpupillary thermotherapy could be an effective method in tumor regression for moderate-to-large-sized RHs showing tumor regression rate of 70%.

• Authors: Hyesun Kim, Jeong H Yi, Hee J Kwon, Christopher S Lee, Sung C Lee
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 34 Issue 12 Pg. 2479-86 (Dec 2014) ISSN: 1539-2864 [Electronic] United States
• PMID: 25072649 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Combined Modality Therapy
• Female
• Hemangioblastoma (diagnosis, physiopathology, therapy)
• Humans
• Hyperthermia, Induced
• Laser Coagulation
• Male
• Middle Aged
• Retinal Neoplasms (diagnosis, physiopathology, therapy)
• Retrospective Studies
• Treatment Outcome
• Visual Acuity (physiology)
• von Hippel-Lindau Disease (complications)