In vitro activity of lomefloxacin against multiply resistant Pseudomonas aeruginosa, Enterobacter cloacae, and Staphylococcus epidermidis.

Abstract

Lomefloxacin is a promising new difluorinated quinolone with good antimicrobial activity and favorable pharmacokinetic properties. The in vitro activity of lomefloxacin was compared to other quinolones, expanded spectrum beta-lactams, and gentamicin. The lomefloxacin MIC90 against multiply resistant strains of P. aeruginosa was 4 mcg/ml, comparable to norfloxacin and ofloxacin. Lomefloxacin was also active against methicillin-resistant S. epidermidis and JK corynebacteria. The role of lomefloxacin in the treatment of infections caused by multiresistant organisms remains to be determined in clinical trials.

• Authors: C A DiVincenzo, K L Shatzer, F R Venezio
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) 1989 May-Jun Vol. 12 Issue 3 Suppl Pg. 13S-16S ISSN: 0732-8893 [Print] United States
• PMID: 2507220 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• Ciprofloxacin
• lomefloxacin
• Norfloxacin

Topics

• Anti-Infective Agents (pharmacology)
• Ciprofloxacin (pharmacology)
• Drug Resistance, Microbial
• Enterobacter (drug effects)
• Enterobacteriaceae
• Fluoroquinolones
• Humans
• Microbial Sensitivity Tests
• Norfloxacin (pharmacology)
• Pseudomonas aeruginosa (drug effects)
• Quinolones
• Staphylococcal Infections (drug therapy)
• Staphylococcus epidermidis (drug effects, isolation & purification)