Abstract | BACKGROUND: METHODS: A retrospective study was conducted. The plasma levels of MR-proADM and MR-proANP were measured in 85 patients hospitalized for LRTIs, 56 of whom with diagnosis of pneumonia and 29 with other LRTIs. RESULTS: The patients with pneumonia had increased MR-proADM levels (median 1.46 nmol/L [IQR 25-75, 0.82-2.02 nmol/L]) compared with the patients with other LRTIs (median 0.88 nmol/mL [0.71-1.39 nmol/L]) (p= 0.04). However, the MR-proANP levels did not show differences between the groups. The optimal threshold of MR-proADM to predict pneumonia was 1.5 nmol/L, which yielded a sensitivity of 51.7% (95% CI, 38.0-65.3), a 79.3% specificity (95% CI, 60.3-92.0), and an odds ratio of 6.64 (95% CI, 1.32-32.85). The combination of this parameter with C-reactive protein in an "and" rule increased the specificity for detecting pneumonia significantly. CONCLUSION: MR-proADM levels (but not MR-proANP levels) are increased in patients with pneumonia although its discriminatory power is moderate.
|
Authors | Agustín Ruiz-González, Aureli Esquerda, José M Porcel, Silvia Bielsa, Horacio Valencia, Gonzalo Cao, Miquel Falguera |
Journal | The open respiratory medicine journal
(Open Respir Med J)
Vol. 8
Pg. 22-7
( 2014)
ISSN: 1874-3064 [Print] United Arab Emirates |
PMID | 25071872
(Publication Type: Journal Article)
|