[The polymorphism of genes of synthesis and metabolism of estrogens and the risk of breast cancer].

Abstract

The genetic polymorphism of enzymes of synthesis and metabolism of estrogens can input into predisposition to breast cancer. The purpose of actual study was to analyze the associations of polymorphic loci CYP17/B1rs10556836, CYP1A 1rs1048943, CYP1A2rs762551, CYP19A1rs2470152 and CYP17A1rs743572 with risk of development of breast cancer in Russian residents of the Western-Siberian region of Russia. The rates of alleles and genotypes of the given loci were determined in sampling of women suffering with breast cancer (n = 670 females) and in control group (480 females without oncological diseases). The sub-groups of patients with breast cancer in pre-menopause--and post-menopause were analyzed separately. The border-line association of locus CYP17A1rs743572 is demonstrated with increasing of risk of breast cancer during pre-menopause (allele C: p = 0.04). Among the rest of polymorphic loci no association was detected.

• Authors: E V Petchkovskiy, A S Shadrina, U A Boyarskih, I A Selezneva, T V Sinkina, A F Lazarev, V D Petrova, M L Filipenko
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 2 Pg. 19-23 (Feb 2014) ISSN: 0869-2084 [Print] Russia (Federation)
• PMID: 25069228 (Publication Type: Journal Article)

Chemical References

• Aromatase
• CYP19A1 protein, human
• CYP1A1 protein, human
• CYP1A2 protein, human
• Cytochrome P-450 CYP1A1
• Cytochrome P-450 CYP1A2
• CYP17A1 protein, human
• Steroid 17-alpha-Hydroxylase

Topics

• Age Factors
• Aged
• Aromatase (genetics)
• Breast Neoplasms (genetics)
• Case-Control Studies
• Cytochrome P-450 CYP1A1 (genetics)
• Cytochrome P-450 CYP1A2 (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Middle Aged
• Polymorphism, Single Nucleotide
• Steroid 17-alpha-Hydroxylase (genetics)