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Updated international clinical recommendations on scar management: part 1--evaluating the evidence.

AbstractBACKGROUND:
There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice.
OBJECTIVE:
To review available data on methods for preventing and treating cutaneous scarring.
MATERIALS AND METHODS:
Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management.
RESULTS:
One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment.
CONCLUSION:
Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.
AuthorsMichael H Gold, Brian Berman, Matteo Tretti Clementoni, Gerd G Gauglitz, Foad Nahai, Crystal Murcia
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 40 Issue 8 Pg. 817-24 (Aug 2014) ISSN: 1524-4725 [Electronic] United States
PMID25068543 (Publication Type: Journal Article, Review)
Topics
  • Cicatrix (therapy)
  • Evidence-Based Medicine
  • Humans
  • Practice Guidelines as Topic
  • Skin Physiological Phenomena

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