Abstract | BACKGROUND: There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice. OBJECTIVE: To review available data on methods for preventing and treating cutaneous scarring. MATERIALS AND METHODS: Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management. RESULTS: One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment. CONCLUSION: Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.
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Authors | Michael H Gold, Brian Berman, Matteo Tretti Clementoni, Gerd G Gauglitz, Foad Nahai, Crystal Murcia |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 40
Issue 8
Pg. 817-24
(Aug 2014)
ISSN: 1524-4725 [Electronic] United States |
PMID | 25068543
(Publication Type: Journal Article, Review)
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Topics |
- Cicatrix
(therapy)
- Evidence-Based Medicine
- Humans
- Practice Guidelines as Topic
- Skin Physiological Phenomena
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