[Five cases of rectal cancer showing remarkable response to suppository administration of tegafur].

Abstract

Five cases of rectal cancer, one male and 4 females, were preoperatively treated with Tegafur suppositories at 1,500 mg per day, for 8 to 21 days (mean, 14 days). These tumors were 2 early cancers and 3 advanced cancers, the configuration of which were one IIa type, one IIa + IIc type and 3 Borrmann 2 types. Their size ranged from 1.3 to 4.2 cm in diameter. Curative resections were performed in all cases, and the examination of the resected specimen revealed marked effects of Tegafur as follows: 1) Reduction of tumor size, 2) disappearance of cancer wall, 3) degeneration of cancer cells and destruction of cancer glands accompanied by fibrous stroma with infiltration of lymphocytes and plasma cells, 4) formation of xanthogranulomatous tissue with foamy histiocytes, which were characteristic findings showing that cancer tissue had been present there. As a result, rectal cancer clearly showed remarkable response to suppository administration of Tegafur for only about two weeks, if the tumor cells were sensitive to the drug.

• Authors: Y Yamanaka, T Morita, M Konn, K Mikami, S Yoshiwara, K Ono
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 9 Pg. 3273-7 (Sep 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2506839 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Suppositories
• Tegafur

Topics

• Adult
• Aged
• Combined Modality Therapy
• Female
• Humans
• Male
• Middle Aged
• Rectal Neoplasms (drug therapy, surgery)
• Suppositories
• Tegafur (administration & dosage, therapeutic use)