Influence of prostaglandin E1 on muscular tissue-PO2 in patients with diabetic gangrene.

Abstract

Intraarterial infusions of short acting vasoactive drugs have been established in the treatment of peripheral occlusive disease. We studied the effect of prostaglandin E1 on the tissue pO2 of the tibialis ant. muscle. Using a fast responding polarographic pO2-probe of the hypodermic needle type, tip diameter 300 microns, we made tissue pO2 investigations in 9 patients with diabetic gangrene. pO2-measurements were done before, during and after administration of 0.2 microgram PGE1/min i.a.. PGE1 led to a slight decrease of the mean muscular pO2 during application followed by a reincrease after the end of infusion. It is known that intraarterial PGE1 infusion leads to an increase of transcutaneous pO2 of the forefoot. Our results show, that there is no increase of tissue pO2 of the tibialis ant. muscle. The reason might be a changed distribution of blood flow in favour of an increased oxygenation of the skin due to PGE1 administration.

• Authors: R Heinrich, H W Krawzak, H Strosche
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 248 Pg. 699-704 ( 1989) ISSN: 0065-2598 [Print] United States
• PMID: 2506745 (Publication Type: Journal Article)

Chemical References

• Carbon Dioxide
• Alprostadil
• Oxygen

Topics

• Aged
• Alprostadil (therapeutic use)
• Carbon Dioxide (blood)
• Diabetic Angiopathies (metabolism, pathology, physiopathology)
• Diabetic Neuropathies (metabolism, pathology, physiopathology)
• Female
• Gangrene (drug therapy)
• Humans
• Hydrogen-Ion Concentration
• Male
• Middle Aged
• Muscles (drug effects, metabolism, pathology)
• Oxygen (analysis, blood)
• Partial Pressure
• Polarography (methods)
• Reference Values