The use of sunitinib in renal cell carcinoma: where are we now?

Abstract

Sunitinib malate (Sutent™) is an inhibitor of multiple protein tyrosine kinases that shows antitumor and antiangiogenic activities. In a randomized Phase III trial of treatment-naive patients with metastatic renal cell carcinoma (mRCC), patients treated with sunitinib showed a significant improvement in progression-free survival compared with those treated with IFN-α. Sunitinib also exhibited antitumor activity in unselected RCC patients, including those with who were refractory to treatment, had non-clear cell histology brain metastases, or an Eastern Cooperative Oncology Group performance status >1. Typical side effects of sunitinib malate are fatigue, asthenia, diarrhea, skin rash, stomatitis, hand-foot skin syndrome, hypothyroidism and hematological abnormalities. Hypertension, other toxicities may serve as biomarkers for improved clinical outcomes in sunitinib treatment. Currently, sunitinib remains the gold standard of care in the treatment of mRCC.

• Authors: Anna M Czarnecka, Cezary Szczylik, Brian Rini
• Journal: Expert review of anticancer therapy (Expert Rev Anticancer Ther) Vol. 14 Issue 9 Pg. 983-99 (Sep 2014) ISSN: 1744-8328 [Electronic] England
• PMID: 25066545 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Indoles
• Pyrroles
• Sunitinib

Topics

• Angiogenesis Inhibitors (adverse effects, pharmacology, therapeutic use)
• Animals
• Antineoplastic Agents (adverse effects, pharmacology, therapeutic use)
• Carcinoma, Renal Cell (drug therapy, pathology)
• Disease-Free Survival
• Humans
• Indoles (adverse effects, pharmacology, therapeutic use)
• Kidney Neoplasms (drug therapy, pathology)
• Neoplasm Metastasis
• Pyrroles (adverse effects, pharmacology, therapeutic use)
• Sunitinib