miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway.

Abstract

The discovery of microRNAs (miRNAs) provided a new avenue for early diagnosis and treatment of GC. MiR-137 has been reported to be under-expressed and involved in various cell processes. However, the role of miR-137 in GC is less known. In this study, we show that miR-137 is under-expressed in GC and functions as a tumor suppressor through targeting Cyclooxygenase-2 (Cox-2), which subsequently suppresses the activation of PI3K/AKT signaling pathway both in vitro and in vivo. Moreover, restored Cox-2 expression partially abolished the tumor suppressive effects of miR-137 in GC cells, suggesting miR-137 may suppress GC carcinogenesis by targeting Cox-2.

• Authors: Yan Cheng, Yang Li, Dong Liu, Rong Zhang, Jun Zhang
• Journal: FEBS letters (FEBS Lett) Vol. 588 Issue 17 Pg. 3274-81 (Aug 25 2014) ISSN: 1873-3468 [Electronic] England
• PMID: 25064845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Chemical References

• MIRN137 microRNA, human
• MicroRNAs
• Cyclooxygenase 2
• Phosphatidylinositol 3-Kinases
• Proto-Oncogene Proteins c-akt

Topics

• Carcinogenesis (genetics)
• Cell Line, Tumor
• Cell Proliferation
• Cyclooxygenase 2 (genetics)
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs (genetics, metabolism)
• Neoplasm Invasiveness
• Phosphatidylinositol 3-Kinases (metabolism)
• Proto-Oncogene Proteins c-akt (metabolism)
• Signal Transduction (genetics)
• Stomach Neoplasms (genetics, pathology)