Abstract | PURPOSE: Children with cholestatic disorders have undergone liver transplantation for intractable pruritus unresponsive to medical therapy even in the absence of liver failure. Biliary diversion procedures interrupt the entero-hepatic circulation of bile acids allowing them to be excreted in the feces thereby lowering the total bile acid pool. We evaluated the outcome of partial internal biliary diversion (PIBD) in children with intractable pruritus from inherited cholestatic disorders. METHODS: The records of children who underwent PIBD over a 4-year period were reviewed for etiology of liver disease, demographic data, preoperative and postoperative biochemical profile and improvement of pruritus. Standard statistical methods were used for analysis. RESULTS: CONCLUSION: To our knowledge, this is the largest reported series of children with PIBD. PIBD is a safe, well-tolerated and effective alternative to liver transplant in children with PFIC and AS who have intractable pruritus in the absence of synthetic liver failure.
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Authors | P Ramachandran, N P Shanmugam, S Al Sinani, V Shanmugam, S Srinivas, M Sathiyasekaran, V Tamilvanan, M Rela |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 30
Issue 10
Pg. 1045-9
(Oct 2014)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 25064227
(Publication Type: Journal Article)
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Topics |
- Bile Ducts
(surgery)
- Biliary Tract Surgical Procedures
(methods)
- Child
- Child, Preschool
- Cholestasis
(complications, surgery)
- Female
- Follow-Up Studies
- Humans
- Infant
- Male
- Pruritus
(etiology, surgery)
- Treatment Outcome
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