Abstract |
This paper presents an implantable encapsulated structure that can deliver localized heating ( hyperthermia) and controlled concentrations of prodigiosin (a cancer drug) synthesized by bacteria (Serratia marcesce (subsp. marcescens)). Prototypical Poly-di-methyl- siloxane (PDMS) packages, containing well-controlled micro-channels and drug storage compartments, were fabricated along with a drug-storing polymer produced by free radical polymerization of Poly(N-isopropylacrylamide)(PNIPA) co-monomers of Acrylamide (AM) and Butyl-methacrylate (BMA). The mechanisms of drug diffusion of PNIPA-base gels were elucidated. Scanning Electron Microscopy (SEM) was also used to study the heterogeneous porous structure of the PNIPA-based gels. The release exponents, n, of the gels were found to between 0.5 and 0.7. This is in the range expected for Fickian (n=0.5). Deviation from Fickian diffusion was also observed (n>0.5) diffusion. The gel diffusion coefficients were shown to vary between 2.1×10(-12)m(2)/s and 4.8×10(-6)m(2)/s. The implications of the results are then discussed for the localized treatment of cancer via hyperthermia and the controlled delivery of prodigiosin from encapsulated PNIPA-based devices.
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Authors | Y Danyuo, J D Obayemi, S Dozie-Nwachukwu, C J Ani, O S Odusanya, Y Oni, N Anuku, K Malatesta, W O Soboyejo |
Journal | Materials science & engineering. C, Materials for biological applications
(Mater Sci Eng C Mater Biol Appl)
Vol. 42
Pg. 734-45
(Sep 2014)
ISSN: 1873-0191 [Electronic] Netherlands |
PMID | 25063175
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Acrylic Resins
- Antineoplastic Agents
- Hydrogels
- poly-N-isopropylacrylamide
- Prodigiosin
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Topics |
- Acrylic Resins
(chemistry)
- Antineoplastic Agents
(chemistry, pharmacokinetics)
- Chemistry, Pharmaceutical
(instrumentation)
- Diffusion
- Drug Delivery Systems
(instrumentation)
- Drug Liberation
- Drug Therapy
(instrumentation)
- Hydrogels
(chemistry)
- Hyperthermia, Induced
- Kinetics
- Prodigiosin
(chemistry, pharmacokinetics)
- Prostheses and Implants
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