The objective of the study was to explore the effects of
olanzapine-fluoxetine combination (OFC) treatment of
major depressive disorders on the quality of life in the acute treatment period. Methods were prospective and observational design. One hundred and three patients of
major depressive disorders were observed. One group of 53 patients received OFC treatment (OFC group); the other group of 50 patients received the treatment of
duloxetine (
duloxetine group). Two groups were needed to be observed 8 weeks. Observed indicators were Hamilton Depression Rating Scale for Depression (HAMD-24) and four factor scores: the slow,
sleep disorders, anxiety/somatization, and hopelessness, Clinical Global Impression-Severity of Illness (CGI-S), WHO quality of life scale (WHOQOL-BREF), and sub-rate measurements. HAMD-24 and four factor scores observation time were assessed before and
after treatment; 1, 2, 4, 8 weeks, WHOQOL-BREF score, and sub-time measurements were assessed before treatment and 8 weeks
after treatment. HAMD-24 scores of OFC patients in the first week were significantly lower than those of the
duloxetine group. The sleep factor scores of OFC patients were significantly lower than those of the
duloxetine group in 4 and 8 weeks. By the end of 8 weeks, OFC group was rated significantly lower than the
duloxetine group in the physical area. In the acute treatment period, OFC treatment effected faster than the single
duloxetine in patients with
major depressive disorders. OFC effected within 1 week and was better than the single
duloxetine in improving the sleep and physical conditions.