Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum.

Abstract

cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4) at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded.

• Authors: Yun Chen, Qian Li, Qingsheng Wu
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 9 Pg. 3175-82 ( 2014) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 25061294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Emulsions
• Stearic Acids
• diammine-diiodoplatin
• stearic acid
• Cisplatin

Topics

• Antineoplastic Agents (chemistry, pharmacokinetics, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cisplatin (analogs & derivatives, chemistry, pharmacokinetics, pharmacology)
• Drug Carriers (chemistry, pharmacokinetics)
• Emulsions (chemistry)
• Humans
• Nanoparticles (chemistry)
• Stearic Acids (chemistry)