Efficacy of topical recombinant human platelet-derived growth factor for treatment of diabetic lower-extremity ulcers: Systematic review and meta-analysis.

Abstract

OBJECTIVE:

Recombinant human platelet-derived growth factor (rhPDGF) is used topically in the treatment of diabetic lower-extremity ulcers. There have been few meta-analyses of the efficacy of rhPDGF in this treatment context. The aim of this study was to perform an updated systematic review and meta-analysis to assess the clinical efficacy of rhPDGF in the treatment of diabetic lower-extremity ulcers.

METHODS:

We searched the MEDLINE, Cochrane Library, EMBASE and Web of Knowledge databases up to April 30, 2014. Studies were identified and selected, and data were extracted by two independent reviewers. The primary efficacy outcome was complete healing rate. Adverse events were also assessed. The studies were evaluated for quality and publication bias.

RESULTS:

A total of 6 randomized controlled trials including 992 patients were selected from 173 identified studies. The studies compared rhPDGF treatment in the context of standard of care (SOC) to placebo or SOC alone. In the absence of study heterogeneity, a fixed-effects model was performed, and the combined odds ratio (OR) indicated a significantly greater complete healing rate in patients treated with rhPDGF compared to placebo or SOC alone. The ORs ranged from 0.58 to 2.77, with a combined OR of 1.53 (95% CI = 1.14 to 2.04, p = 0.004). A sensitivity analysis (leave-one-out method) indicated good study reliability, and a funnel plot with Egger test showed no publication bias.

CONCLUSION:

These results indicate that rhPDGF is efficacious in the treatment of diabetic lower-extremity ulcers.

• Authors: Xiao-hong Zhao, Hai-feng Gu, Zhe-rong Xu, Qin Zhang, Xue-ying Lv, Xiao-jun Zheng, Yun-mei Yang
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 63 Issue 10 Pg. 1304-13 (Oct 2014) ISSN: 1532-8600 [Electronic] United States
• PMID: 25060693 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Platelet-Derived Growth Factor
• Recombinant Proteins

Topics

• Administration, Topical
• Diabetes Complications (drug therapy)
• Female
• Foot Ulcer (drug therapy)
• Humans
• Lower Extremity
• Male
• Middle Aged
• Platelet-Derived Growth Factor (adverse effects, therapeutic use)
• Randomized Controlled Trials as Topic
• Recombinant Proteins (adverse effects, therapeutic use)
• Wound Healing (drug effects)