Association of penicillin-tolerant streptococci with epidemics of streptococcal pharyngitis in closed communities.

Abstract

The association of penicillin-tolerant streptococci with reported epidemics of streptococcal pharyngitis in Israel was studied. The streptococcal strains had been isolated during 11 epidemics of community-acquired pharyngitis and 6 food-borne epidemics of pharyngitis occurring in the last 15 years. Strains were stocked lyophilized. Isolates were defined as tolerant if the MBC/MIC ratio for penicillin was greater than or equal to 32. All 122 group A streptococcal strains isolated during the epidemics of community-acquired infection showed tolerance to penicillin. In contrast, none of the 52 strains from food-borne epidemics (24 group A, 18 group C and 8 group G) was tolerant.

• Authors: R Dagan, M Ferne
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 8 Issue 7 Pg. 629-31 (Jul 1989) ISSN: 0934-9723 [Print] Germany
• PMID: 2506025 (Publication Type: Journal Article)

Chemical References

• Penicillins

Topics

• Disease Outbreaks
• Drug Tolerance
• Food Microbiology
• Humans
• Israel
• Penicillins (pharmacology)
• Pharyngitis (epidemiology, microbiology, transmission)
• Streptococcal Infections (epidemiology, microbiology, transmission)
• Streptococcus pyogenes (drug effects, isolation & purification)