Abstract | RATIONALE: OBJECTIVES: The present study used extended access nicotine self-administration (0.03 mg/kg/infusion, 21 h/day, 4 days) with intermittent periods of deprivation (3 days) for 14 weeks, to test the hypothesis that this model enhances nicotine seeking and produces distinct responses in hippocampal neurogenesis when compared with limited access (1 h/day, 4 days) intake. Animals in the extended access group were either perfused prior to or following their final deprivation period, whereas animals in the limited access group were perfused after their last session. RESULTS: Limited- and extended access nicotine self-administration with periodic deprivation did not affect proliferation and differentiation of oligodendrocyte progenitors in the medial prefrontal cortex (mPFC). Conversely, extended access nicotine self-administration with periodic deprivation enhanced proliferation and differentiation of hippocampal neural progenitors. Furthermore, in the hippocampus, the number of differentiating NeuroD-labeled cells strongly and positively correlated with enhanced nicotine seeking in rats that experienced extended access nicotine self-administration. CONCLUSIONS: These findings demonstrate that extended versus limited access to nicotine self-administration differentially affects the generation of new oligodendroglia and new neurons during adulthood. The increases in the number of differentiating cells in extended access nicotine self-administering rats may consequently contribute to aberrant hippocampal neurogenesis and may contribute to maladaptive addiction-like behaviors dependent on the hippocampus.
|
Authors | Ami Cohen, Matthew T Soleiman, Reneta Talia, George F Koob, Olivier George, Chitra D Mandyam |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 232
Issue 2
Pg. 453-63
(Jan 2015)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 25059540
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Animals
- Behavior, Addictive
- Hippocampus
(drug effects, pathology)
- Male
- Neural Stem Cells
(drug effects, pathology)
- Neurogenesis
- Neuronal Plasticity
(drug effects)
- Neurons
(drug effects, pathology)
- Nicotine
(administration & dosage)
- Rats
- Rats, Wistar
- Self Administration
- Tobacco Use Disorder
(pathology)
|