HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The effect of dinitrosyl iron complexes with glutathione and S-nitrosoglutathione on the development of experimental endometriosis in rats: a comparative studies.

Abstract
It has been established that intraperitoneal bolus administration of S-nitrosoglutathione (GS-NO) (12.5μmoles/kg; 10 injections in 10 days), beginning with day 4 after transplantation of two 2-mm autologous fragments of endometrial tissue onto the inner surface of the abdominal wall of rats with surgically induced (experimenta) endometriosis failed to prevent further growth of endometrioid (EMT) and additive tumors, while treatment of animals with dinitrosyl iron complexes (DNIC) with glutathione (12.5μmoles/kg, 10 injections in 10 days) suppressed tumor growth virtually completely. The histological analysis of EMT samples of GS-NO-treated rats revealed pathological changes characteristic of control (non-treated with GS-NO or DNIC) rats with experimental endometriosis. EPR studies established the presence of the active form of ribonucleotide reductase, a specific marker for rapidly proliferating tumors, in EMT samples of both control and GS-NO-treated animals. Noteworthy, in small-size EMT and adjacent tissues of DNIC-treated rats the active form of ribonucleotide reductase and pathological changes were not found.
AuthorsEvgeniya N Burgova, Nikolai А Tkachev, Oksana V Paklina, Vasak D Mikoyan, Leila V Adamyan, Anatoly F Vanin
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 741 Pg. 37-44 (Oct 15 2014) ISSN: 1879-0712 [Electronic] Netherlands
PMID25058904 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Drug Combinations
  • Nitrogen Oxides
  • S-Nitrosoglutathione
  • dinitrosyl iron complex
  • Iron
  • Glutathione
Topics
  • Animals
  • Drug Combinations
  • Endometriosis (pathology, prevention & control)
  • Female
  • Glutathione (administration & dosage)
  • Iron (administration & dosage)
  • Nitrogen Oxides (administration & dosage)
  • Rats
  • Rats, Wistar
  • S-Nitrosoglutathione (administration & dosage)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: