Abstract |
Thirty cows naturally infected with Brucella abortus were treated by various routes, using free or liposomal streptomycin or a combination of liposomal streptomycin and a long-acting oxytetracycline preparation. Of 21 cows treated with liposomal streptomycin alone, 3 (14%) were culture negative and 3 had 10 or fewer bacterial colonies isolated from tissues obtained at necropsy. Thirteen (62%) cows continued to shed organisms in udder secretions and were considered treatment failures. Of 9 cows that were given a combination of liposomal streptomycin and long-acting oxytetracycline, 5 (56%) were cured, 3 had 10 or fewer colonies on culture plates of tissue after necropsy and only 1 continued to shed B abortus in udder secretions after treatment. Eleven cows were given streptomycin liposomes by intramammary infusion with or without IM administration of long-acting oxytetracycline. The most effective regimen consisted of 2 intramammary infusions of streptomycin liposomes and 2 doses of oxytetracycline administered IM. Of 5 cows treated thusly, 2 were cured and all others had fewer than 10 B abortus colonies isolated from tissues obtained at necropsy.
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Authors | P Nicoletti, R P Lenk, M C Popescu, C E Swenson |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 50
Issue 7
Pg. 1004-7
(Jul 1989)
ISSN: 0002-9645 [Print] United States |
PMID | 2505648
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- Liposomes
- Oxytetracycline
- Streptomycin
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Topics |
- Animals
- Brucella abortus
(drug effects)
- Brucellosis, Bovine
(drug therapy, metabolism, microbiology)
- Cattle
- Drug Carriers
- Drug Therapy, Combination
(administration & dosage, therapeutic use)
- Female
- Liposomes
- Mammary Glands, Animal
(metabolism, microbiology)
- Oxytetracycline
(administration & dosage, therapeutic use)
- Streptomycin
(administration & dosage, blood, therapeutic use)
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