Abstract | AIM: MATERIAL AND METHODS: A total of 111 patients, 57 with ICP and 54 controls, were evaluated for preterm birth (PTB), meconium-stained amnion (MSA), neonatal intensive-care unit admission and asphyxia. We further classified the ICP group as mild and severe. Logistic regression was performed to evaluate the associated biochemical and clinical parameters with adverse perinatal outcomes. RESULTS: In the ICP group, PTB, asphyxia, admission to neonatal intensive-care unit, and MSA were more frequently observed (P = 0.001, P = 0.027, P = 0.006 and P = 0.030, respectively). In subgroup analysis, PTB was more frequent in severe ICP cases than in mild cases (P = 0.028). Fasting and ppTBA were positively correlated with serum aspartate aminotransferase and alanine aminotransferase levels. Postprandial TBA and difference between fasting and postprandial TBA levels were associated with asphyxia (P = 0.014 and P = 0.023, respectively). Gestational age at diagnosis and fTBA were associated with adverse perinatal outcomes (P = 0.001 and P = 0.025, respectively). CONCLUSION: Postprandial TBA and difference of fasting and postprandial TBA are associated with asphyxia in ICP. The gestational age at diagnosis and fTBA are associated with adverse perinatal outcomes.
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Authors | Ayla Sargın Oruç, Berna Seçkin, Nagihan Özcan, Sebnem Özyer, Özlem Uzunlar, Nuri Danışman |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 40
Issue 7
Pg. 1883-9
(Jul 2014)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 25056466
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology. |
Chemical References |
- Bile Acids and Salts
- Biomarkers
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Topics |
- Adult
- Bile Acids and Salts
(blood)
- Biomarkers
(blood)
- Case-Control Studies
- Cholestasis, Intrahepatic
(blood, diagnosis, physiopathology)
- Fasting
- Female
- Humans
- Postprandial Period
- Pregnancy
- Pregnancy Complications
(blood, diagnosis, physiopathology)
- Pregnancy Outcome
- Prognosis
- Prospective Studies
- Severity of Illness Index
- Turkey
- Young Adult
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